Q: 28 year old male is recently started on Isoniazide (INH) after he was tested postive for PPD during routine employment exam. He is now admitted with seizure. What is the treatment

Answer: IV Pyridoxine (Vitamin B6)

Five grams of IV pyridoxine given over 5-10 minutes is sufficient to abolish the neurologic effects of isoniazid in most cases. Repeat dosing may be required for persistent seizure activity. Patients usually do not respond to most of the antiepileptics.